Grand Challenges India: New Approaches to Characterize the Global Burden of Antimicrobial Resistance

Organisation:  Bill & Melinda Gates Foundation

Apply By:  25 May . 2018

Grand Challenges India: New Approaches to Characterize the Global Burden of Antimicrobial Resistance

Appropriate antibiotic use has the power to save lives in the most vulnerable communities, and antimicrobial resistance (AMR) impacts multiple global health priority areas: HIV/AIDS, tuberculosis, maternal and neonatal health, pneumonia, and enteric and diarrheal diseases. It is critical to better understand the prevalence of AMR and its impact on mortality in developing countries so that access to appropriate antibiotics is ensured while inappropriate use of antibiotics is limited. In particular, there is a need to better understand resistance in bacterial infections of newborns and young children – and to this end, understanding what is the prevalence of AMR in the community, how it impacts mortality, and how it impacts health targets. Tackling AMR will require a global, coordinated approach and the linking together of different research communities for new perspectives on the problem.

What we are looking for:

We seek new approaches that have the potential to transform public health action on a regional or global scale by identifying and filling gaps in knowledge on the burden of resistance to antibacterial agents – we are not seeking incremental improvements in typical disease surveillance solutions. Specifically, we seek projects that propose innovation in the following areas:

  • Data sources: Pilot tests of new sources of data, particularly those that would bring together different research communities for new perspectives on the problem
  • Analytical methods: Pilot tests of bioinformatics approaches, including those that combine or connect existing databases in novel ways
  • Biomarkers: Pilot tests of new biomarkers or combinations of biomarkers that could lead to new understanding of the actionable implications of antimicrobial resistance surveillance data
  • Low-cost technologies and products: Exploratory work in developing new technologies and products, including 1) those that specifically target improved infection prevention and control in healthcare settings to reduce reliance on healthcare provider behavior change, and 2) technologies to remove antibiotics from effluents

We will give highest priority to those projects that:

  • Pilot test approaches that could be added to existing surveillance platforms, since we are not seeking to create new surveillance platforms
  • Incorporate multiple of the areas of innovation listed above
  • Could contribute to a portfolio of funded projects that addresses a country’s regional diversity and the diversity of vulnerable populations
  • Explain how proposed approaches will be tested so that they have the highest likelihood of being relevant for implementation in the country’s public health system

Deadline: 25 MAY 2018 - 12:00PM PDT

For more information please check the Link


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