Applications Invited for Breakthrough T1D Grant

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About the Organization

Since our founding in 1970, Breakthrough T1D has played a critical role in every major type 1 diabetes milestone.

Founded in 1970 by families whose loved ones had been diagnosed with type 1 diabetes (T1D), Breakthrough T1D is a tax-exempt nonprofit 501(c)3 organization.

We are opening doors that were once closed by T1D diagnosis. We lead the way to more effective solutions by connecting the brightest minds to advance treatments, influence policy, and improve access to care.​ By driving innovation forward, Breakthrough T1D will make type 1 diabetes a condition of the past.

Our mission: Accelerating life-changing breakthroughs to cure, prevent, and treat type 1 diabetes and its complications.

Our purpose: As we drive toward curing type 1 diabetes, we help make everyday life better for the people who face it.

About the Grant

Across the country and around the world, leading scientists are working to solve the many parts of the type 1 diabetes puzzle to deliver cures and life-improving breakthroughs. Breakthrough T1D helps fund their work, connects their research and propels advances forward with the aim of getting solutions to market as quickly as possible. As the leading charitable funder of diabetes research worldwide, Breakthrough T1D offers a wide variety of grants and fellowships to qualified researchers. We encourage all qualified researchers interested in solving the clinical and scientific problems associated with type 1 diabetes to apply for funding and become a part of our winning team.

Breakthrough T1D is a global funding agency with a substantial proportion of its grants awarded outside the United States. We encourage all qualified researchers interested in addressing the scientific and clinical challenges and gaps to cure type 1 diabetes and its complications to apply for funding. Decisions on funding are based on the quality, mission relevance, and priority of the proposed research. Breakthrough T1D encourages submission of innovative, high-risk/high-reward, field-changing research proposals to accelerate its mission. Breakthrough T1D has multiple funding mechanisms, including Strategic Research Agreements, Innovative Grants, and Industry Grants to build a diverse research portfolio, to provide the research community with alternative approaches to address the foundation’s mission, and to provide research training opportunities to attract new talent to the field.

Breakthrough T1D Grant Mechanisms:

Ongoing Opportunities

• Strategic Research Agreement

Brief Description: Designed to provide research funding for investigators to address critical gaps and challenges and make breakthroughs in type 1 diabetes research.

Institutional Eligibility: Domestic & foreign non-profit organizations; public & private universities, colleges, hospitals, laboratories; units of state & local governments; eligible agencies of the federal government.

Applicant Eligibility: Required: MD, DMD, DVM, PhD, or equivalent and faculty position or equivalent.

Human Subjects Research: For a project proposing human subject research, please review the Human Subject Research Guidelines.

Description: Breakthrough T1D’s Strategic Research Agreements provide research funding for investigators to address critical gaps and challenges and make breakthroughs in type 1 diabetes research. The Strategic Research Agreement is a partnership between Investigator(s) and Breakthrough T1D scientists to accelerate Breakthrough T1D’s mission through support of cutting-edge scientific investigation. Further, this mechanism embodies cooperative development of a research plan, regular reporting on milestones and interaction with Breakthrough T1D scientists prior to and during the award period. The budget and duration of funding are variable and continued funding is based on satisfactory effort and progress on milestones. Submission of an application requires permission from Breakthrough T1D and is initiated with an LOI submitted to Project Concept Call in RMS360, an open Breakthrough T1D Funding Opportunity, or by direct invitation from Breakthrough T1D Staff.

Eligibility: Applicants must hold an MD, DMD, DVM, PhD, or equivalent and have a faculty position or equivalent at a college, university, medical school, company, or other research facility. Applications may be submitted by domestic and foreign non-profit organizations, public and private, such as colleges, universities, hospitals, laboratories, units of state and local governments, and eligible agencies of the federal government. Ordinarily, for-profit organizations will not be considered, except under special circumstances. See the Industry Discovery & Development Partnerships section for a description of special programs for for-profit entities. There are no citizenship requirements. To assure continued excellence and diversity among applicants and awardees, Breakthrough T1D welcomes applications from all qualified individuals and encourages applications from persons with disabilities, women, and members of minority groups underrepresented in the sciences.

Clinical Strategic Research Agreement

Description: Breakthrough T1D Clinical SRAs are intended to support research programs that qualify under the Breakthrough T1D clinical review process. This funding mechanism is intended to support clinical trials to test therapeutic approaches as well as non-interventional patient-oriented studies that are intended to lead to the development of clinical interventions and monitoring tools (such as biomarkers) for diabetes and its complications. Applications for Strategic Research Agreement – Clinical must be goal oriented and closely focused on the Breakthrough T1D mission.

Clinical Application Guidelines: All applications involving human subject research must include supplemental information to address subject safety, study design and investigational product information. More details can be found in the Human Subject Research Guidelines. All applications that receive a funding recommendation after scientific review will undergo clinical review where a subsequent review of the study protocol and supporting documents will be performed.

Outcomes Beyond A1C Resources: The Steering Committee of the T1D Outcomes Program has defined the following outcomes: hypoglycemia, hyperglycemia, time-in-range, and diabetic ketoacidosis (DKA). Breakthrough T1D requires that all newly funded clinical studies incorporate the appropriate outcomes. Further, outcomes incorporated into a study should be consistent with the definitions from the publication, and we recommend their usage as endpoints in all T1D studies. Protocols that include measurement of these outcomes that are not defined per the publication must provide justification prior to grant approval.

Evaluation: Clinical SRAs will be evaluated for scientific merit, clinical standards of care for the proposed patient population and adherence to Good Clinical Practice. The scientific review criteria include:

• Relevance to the objectives of Breakthrough T1D
• Scientific, technical, or medical significance of the research proposal
• Innovative quality of the proposed study
• Soundness of the clinical study design
• Availability of sufficient pre-clinical data to justify the proposed clinical study
• Qualifications and research experience of the principal investigators and collaborators Consideration of the potential benefits and risks to patients who will be involved in the research, plans to limit risks, and other ethical considerations
• Availability of resources and facilities necessary for the study
• Appropriateness of the proposed budget in relation to the proposed research

 

• Innovative Grant

Brief Description: The Innovative Grant program solicits proposals for highly innovative research with significant potential to accelerate the mission of Breakthrough T1D. Proposals should address key outstanding questions and have the potential to lead to a change in the current paradigm or conventional wisdom and/or lead to a groundbreaking discovery.

Institutional Eligibility: Domestic & foreign non-profit organizations; public & private universities, colleges, hospitals, & laboratories; units of state and local governments; eligible agencies of the federal government.

Applicant Eligibility: Required: MD, DMD, DVM, PhD or equivalent and faculty position or equivalent

Proposal: Access and submit full applications (including research plans) via RMS360.

Terms: Innovative: 200,000 USD maximum/year for one year, including up to 10% for indirect costs.

Human Subjects Research: For a project proposing Human Subject Research, please review the Scientific Guidelines.

Description: Breakthrough T1D provides seed funding for highly innovative research with significant potential to accelerate the mission of Breakthrough T1D. Proposals should address key outstanding questions and have the potential to lead to a change in the current paradigm or conventional wisdom and/or lead to a groundbreaking discovery. Preliminary data is not required in the proposal but the underlying premise, goal, or hypothesis must be plausible and testable and the proposal must be focused with a well-defined goal that is achievable within the timeframe of the award. The Innovative Grant is not intended to support proposals aiming to incrementally advance existing hypotheses, ongoing areas of research or proposals with the sole goal of generating novel reagents or resources.

Eligibility: Proposals may be submitted by domestic and foreign non-profit organizations, public and private, such as universities, colleges, hospitals, laboratories, units of state and local governments, and eligible agencies of the federal government. Innovative (but not pilot and research tool) proposals from for-profit organizations will also be considered. Applicants must hold an M.D., D.M.D., D.V.M., Ph.D., or equivalent and have a faculty position or equivalent at a college, university, medical school, or other research facility. There are no citizenship requirements for this program. To assure continued excellence and diversity among applicants and awardees, Breakthrough T1D welcomes proposals from all qualified individuals and encourages proposals from persons with disabilities, women, and members of minority groups underrepresented in the sciences.

How to Apply

Access and submit full applications (including research plans) via RMS360.

For more information please check the Link

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